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Sphk1tm1Rlp
Targeted Allele Detail
Nomenclature
Symbol: Sphk1tm1Rlp
Name: sphingosine kinase 1; targeted mutation 1, Richard L Proia
MGI ID: MGI:3526071
Synonyms: SK1-, Sphk1-, SphK1 KO
Gene: Sphk1  Location: Chr11:116530925-116536674 bp, + strand  Genetic Position: Chr11, 81.42 cM, cytoband E2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:95168
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neo replaced exons 3-5 and the 5' end of exon 6, deleting sequence corresponding to the putative lipid kinase catalytic domain, which contains the conserved domains C1, C2, C3 and part of C4, and a putative nucleotide binding motif. Absence of mRNA was demonstrated in kidney samples by Northern blot and RT-PCR analyses. (J:95168)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Sphk1 Mutation:  4 strains or lines available
References
Original:  J:95168 Allende ML, et al., Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720. J Biol Chem. 2004 Dec 10;279(50):52487-92
All:  80 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/26/2019
MGI 6.14
The Jackson Laboratory