Phenotypes associated with this allele
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sphk1tm1Rlp mutation
(2 available);
any
Sphk1 mutation
(30 available)
|
|
|
mortality/aging
|
|
• mutants are protected from LPS lethality
|
immune system
|
|
• increase in IL-1beta levels in mesenteric lymph nodes but reduced levels in the lungs after LPS challenge
|
|
|
• mesenteric lymph nodes are 3 times larger than in wild-type 18 hours after LPS challenge
|
|
|
• mutants exhibit a similar level of initial development of inflammation as wild-type mice in response to severe challenge with lipopolysaccharide (LPS), however attenuation of the inflammation occurs 18 hours after challenge while wild-type mice succumb to the infection
|
homeostasis/metabolism
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sphk1tm1Rlp mutation
(2 available);
any
Sphk1 mutation
(30 available)
|
|
|
normal phenotype
|
|
• homozygous null mice are viable, fertile, and without any obvious abnormalities, however serum and plasma levels of sphingosine-1-phosphate were reduced to less than 50% of wild-type
|
mortality/aging
|
|
• 17% of embryos are not viable at E11.5, 70% die by E12.5 and none survive past E13.5
|
cardiovascular system
|
|
• remodeling defects of blood vessels in the head are apparent at E10.5. showing the formation of enlarged, dilated blood vessels and an aberrant anastomotic network
|
|
|
• wall of the dorsal aorta is poorly developed at E11.5
|
|
|
• endothelial cells are severely defective in all blood vessels in the mesenchymal region of the head and some contain vacuoles
|
|
|
• the smooth muscle covering of the aorta is patchy and incomplete
|
|
|
• severely affected embryos exhibit widespread hemorrhaging in areas other than the brain such as the spinal cord and mandible
|
|
|
• exhibit cranial hemorrhage by E11.5 and E12.5, predominately in the cranial mesenchymal region
|
|
|
• hemorrhaging in the cranial mesenchymal region is sometimes accompanied by intraventricular hemorrhages
|
muscle
|
|
• the smooth muscle covering of the aorta is patchy and incomplete
|
nervous system
|
|
• exhibit cranial hemorrhage by E11.5 and E12.5, predominately in the cranial mesenchymal region
|
|
|
• hemorrhaging in the cranial mesenchymal region is sometimes accompanied by intraventricular hemorrhages
|
|
|
• apoptosis is increased in the neuroepithelium of the rhombencephalon
|
|
|
• apoptosis is increased in the neuroepithelium of the mesencephalon
|
|
|
• apoptosis is increased in the neuroepithelium of the mesencephalon and the rhombencephalon
|
|
|
• embryos exhibit a very thin, poorly developed wall of neuroepithelium and an irregularly shaped neuroepithelial layer in the whole brain
|
|
|
• embryos exhibit a very thin, poorly developed wall of neuroepithelium
|
|
|
• impaired anterior neural tube closure
|
|
|
• ventricular dilation at E11.5
|
|
|
• seen in 18% of embryos at E10.5, 13% at E11.5 and in 20% at E12.5, however do not observe spina bifida
|
embryo
|
|
• embryos exhibit a very thin, poorly developed wall of neuroepithelium and an irregularly shaped neuroepithelial layer in the whole brain
|
|
|
• embryos exhibit a very thin, poorly developed wall of neuroepithelium
|
|
|
• impaired anterior neural tube closure
|
homeostasis/metabolism
cellular
|
|
• apoptosis is increased in the neuroepithelium of the rhombencephalon
|
|
|
• apoptosis is increased in the neuroepithelium of the mesencephalon
|
|
|
• apoptosis is increased in the neuroepithelium of the mesencephalon and the rhombencephalon
|
Analysis Tools