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Targeted Allele Detail
Symbol: Erbb2tm8(Erbb2)Mul
Name: erb-b2 receptor tyrosine kinase 2; targeted mutation 8, William J Muller
MGI ID: MGI:3525444
Synonyms: ErbB2KI, Flneo NeuNT, NeuNT, neuNTki
Gene: Erbb2  Location: Chr11:98412470-98437716 bp, + strand  Genetic Position: Chr11, 61.75 cM, cytoband D
Germline Transmission:  Earliest citation of germline transmission: J:61202
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Conditional ready, Inserted expressed sequence)
Mutations:    Insertion, Intragenic deletion
Erbb2tm8(Erbb2)Mul expresses 1 gene
Mutation detailsExon 1 of the endogenous Erbb2 allele was replaced by a lox-P flanked PGK-neomycin-HSV polyA cassette, followed by an oncogenic Erbb2 cDNA containing an activating point mutation in the transmembrane domain. (J:61202)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Erbb2 Mutation:  32 strains or lines available
Original:  J:61202 Andrechek ER, et al., Amplification of the neu/erbB-2 oncogene in a mouse model of mammary tumorigenesis. Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3444-9
All:  20 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.11
The Jackson Laboratory