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Targeted Allele Detail
Symbol: Erbb2tm8(Erbb2)Mul
Name: erb-b2 receptor tyrosine kinase 2; targeted mutation 8, William J Muller
MGI ID: MGI:3525444
Synonyms: ErbB2KI, Flneo NeuNT, NeuNT, neuNTki
Gene: Erbb2  Location: Chr11:98412470-98437716 bp, + strand  Genetic Position: Chr11, 61.75 cM, cytoband D
Germline Transmission:  Earliest citation of germline transmission: J:61202
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Conditional ready, Inserted expressed sequence)
Mutations:    Insertion, Intragenic deletion
Erbb2tm8(Erbb2)Mul expresses 1 gene
Mutation detailsExon 1 of the endogenous Erbb2 allele was replaced by a lox-P flanked PGK-neomycin-HSV polyA cassette, followed by an oncogenic Erbb2 cDNA containing an activating point mutation in the transmembrane domain. (J:61202)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Erbb2 Mutation:  21 strains or lines available
Original:  J:61202 Andrechek ER, et al., Amplification of the neu/erbB-2 oncogene in a mouse model of mammary tumorigenesis. Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3444-9
All:  19 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.07
The Jackson Laboratory