Atp1a2^tm2Kwk
Targeted Allele Detail

Summary

• Symbol: Atp1a2^tm2Kwk
• Name: ATPase, Na+/K+ transporting, alpha 2 polypeptide; targeted mutation 2, Kiyoshi Kawakami
• MGI ID: MGI:3522421
• Synonyms: N-KO
• Gene: Atp1a2 Location: Chr1:172099276-172125631 bp, - strand Genetic Position: Chr1, 79.6 cM
• Alliance: Atp1a2^tm2Kwk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94810
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette was inserted into exon 2 in the opposite orientation of transcription. No alpha2 isoform was found in the membrane fraction of mutant brain samples by Western blot analysis. (J:94810)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atp1a2 Mutation: 61 strains or lines available

References

• Original: J:94810 Ikeda K, et al., Malfunction of respiratory-related neuronal activity in Na+, K+-ATPase alpha2 subunit-deficient mice is attributable to abnormal Cl- homeostasis in brainstem neurons. J Neurosci. 2004 Nov 24;24(47):10693-701
• All: 4 reference(s)