Analysis Tools
homeostasis/metabolism
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• increased extracellular GABA in the brain
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mortality/aging
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• died within 10-15 min after birth from lack of breathing
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behavior/neurological
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• lacked response to pinch at birth
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• lacked spontaneous body movement at birth
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respiratory system
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• failed to breathe or showed gasping-like mouth opening two to three times and died within 10-15 min
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nervous system
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• respiratory neurons in the ventrolateral medulla recovered more slowly after electrical stimulation
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• neurons in the facial nucleus region became persistently depolarized and could not produce action potentials
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• spontaneous respiratory rhythm activity was absent in the fourth cervical ventral root
• no response following stimulation of ventrolateral medulla at 0 min
• high intracellular chloride concentrations in ventrolateral medulla neurons at E18.5
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• absent inhibitory neural activities in the respiratory neurons of the ventrolateral medulla
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