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Adam10tm1Psa
Targeted Allele Detail
Nomenclature
Symbol: Adam10tm1Psa
Name: a disintegrin and metallopeptidase domain 10; targeted mutation 1, Paul Saftig
MGI ID: MGI:3522353
Synonyms: Adam10-
Gene: Adam10  Location: Chr9:70678997-70780229 bp, + strand  Genetic Position: Chr9, 39.53 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:94943
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsThe 5' exon was interrupted by the insertion of a neomycin expression cassette. This introduces a premature stop codon into the ORF. RT-PCR and Northern blot analysis confirmed the absence of transcription. Western blot analysis demonstrated the absence of a protein product. (J:94943)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adam10 Mutation:  21 strains or lines available
References
Original:  J:94943 Hartmann D, et al., The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts. Hum Mol Genet. 2002 Oct 1;11(21):2615-24
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/14/2017
MGI 6.08
The Jackson Laboratory