Igh^tm3.1Cog
Targeted Allele Detail

Summary

• Symbol: Igh^tm3.1Cog
• Name: immunoglobulin heavy chain complex; targeted mutation 3.1, Michel Cogne
• MGI ID: MGI:3522204
• Synonyms: delta hs3b4, delta hs3b/hs4, Rr152^tm3.1Cog
• Gene: Igh Location: Chr12:113222388-115973574 bp, - strand Genetic Position: Chr12, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:71300
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Modified regulatory region, Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This targeted mutation deletes a 6-kilobase genomic DNA segment containing hs3b (Rr155) and hs4 (Rr156), the two most distant of four 3' transcriptional enhancers residing within the approximately 26 kilobase locus control region downstream of the Igh complex (3'RR or Rr152). The original targeting event replaced hs3b and hsb4 with a loxP-flanked neomycin resistance gene cassette. Crossing of chimeric founder mice with mice expressing Cre recombinase under control of the EIIa promoter yielded progeny in which the neo cassette was deleted in the germline. (J:71300)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Igh Mutation: 43 strains or lines available

References

• Original: J:71300 Pinaud E, et al., Localization of the 3' IgH locus elements that effect long-distance regulation of class switch recombination. Immunity. 2001 Aug;15(2):187-99
• All: 7 reference(s)