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Cebpatm1Dgt
Targeted Allele Detail
Nomenclature
Symbol: Cebpatm1Dgt
Name: CCAAT/enhancer binding protein (C/EBP), alpha; targeted mutation 1, Daniel G Tenen
MGI ID: MGI:3522010
Synonyms: C/EBPalphaF
Gene: Cebpa  Location: Chr7:35119293-35121928 bp, + strand  Genetic Position: Chr7, 21.02 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:94682
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsLoxP sites were inserted to flank the single exon and a neo cassette inserted downstream of the exon. Western blot of whole-cell lysates of adult liver and total bone marrow cells showed that protein was present in mutants. (J:94682)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Cebpa Mutation:  9 strains or lines available
References
Original:  J:94682 Zhang P, et al., Enhancement of hematopoietic stem cell repopulating capacity and self-renewal in the absence of the transcription factor C/EBP alpha. Immunity. 2004 Dec;21(6):853-63
All:  27 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/20/2020
MGI 6.16
The Jackson Laboratory