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Targeted Allele Detail
Symbol: Del(11Cops3-Gid4)2Jrl
Name: deletion, Chr 11, James R Lupski 2
MGI ID: MGI:3521986
Synonyms: Del(11Csn3-4933439F18Rik)2Jrl, Del2Jrl, Df(11)17-1
Gene: Del(11Cops3-Gid4)2Jrl  Location: unknown  Genetic Position: Chr11, Syntenic
Germline Transmission:  Earliest citation of germline transmission: J:94405
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Allele Type:    Targeted
Mutation:    Intergenic deletion
  Del(11Cops3-Gid4)2Jrl involves 24 genes/genome features (Gm16062, Cops3, Nt5m ...) View all
Mutation detailsA deletion between Cops3 and Gid4 (previously, 4933439F18Rik) was engineered in ES cells by insertion of complementary partial Hprt-loxP constructs at each site. Insertion at Cops3 was specifically targeted whereas insertion in intron 3 of Gid4 was a random insertion brought about using a V15 retrovirus. Cre recombinase actived deleted the intervening region and reconstructed the Hprt minigene for selection purposes. Two additional, phenotypically identical, deletions were created in which the loxP-Hprt partial gene was inserted in intron 5 of Gid4 (MGI:3521943 and MGI:3521944). (J:94405)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Del(11Cops3-Gid4)2Jrl Mutation:  0 strains or lines available
Original:  J:94405 Yan J, et al., Reduced penetrance of craniofacial anomalies as a function of deletion size and genetic background in a chromosome engineered partial mouse model for Smith-Magenis syndrome. Hum Mol Genet. 2004 Nov 1;13(21):2613-24
All:  3 reference(s)

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MGI 6.01
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