Pdk2^tm1Rhar
Targeted Allele Detail

Summary

• Symbol: Pdk2^tm1Rhar
• Name: pyruvate dehydrogenase kinase, isoenzyme 2; targeted mutation 1, Robert A Harris
• MGI ID: MGI:3521813
• Gene: Pdk2 Location: Chr11:94917084-94932180 bp, - strand Genetic Position: Chr11, 59.01 cM
• Alliance: Pdk2^tm1Rhar page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:172411
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 and part of exon 2 were deleted by insertion of a neomycin resistance cassette. Western blot analysis confirmed the absence of translation product. (J:172411)

Expression

In Mice Carrying this Mutation:

4 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pdk2 Mutation: 23 strains or lines available

References

• Original: J:172411 Dunford EC, et al., PDH activation during in vitro muscle contractions in PDH kinase 2 knockout mice: effect of PDH kinase 1 compensation. Am J Physiol Regul Integr Comp Physiol. 2011 Jun;300(6):R1487-93
• All: 11 reference(s)