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Pdk2tm1Rhar
Targeted Allele Detail
Nomenclature
Symbol: Pdk2tm1Rhar
Name: pyruvate dehydrogenase kinase, isoenzyme 2; targeted mutation 1, Robert A Harris
MGI ID: MGI:3521813
Gene: Pdk2  Location: Chr11:94917084-94932180 bp, - strand  Genetic Position: Chr11, 59.01 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:172411
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1 and part of exon 2 were deleted by insertion of a neomycin resistance cassette. Western blot analysis confirmed the absence of translation product. (J:172411)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 4 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pdk2 Mutation:  17 strains or lines available
References
Original:  J:172411 Dunford EC, et al., PDH activation during in vitro muscle contractions in PDH kinase 2 knockout mice: effect of PDH kinase 1 compensation. Am J Physiol Regul Integr Comp Physiol. 2011 Jun;300(6):R1487-93
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory