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Targeted Allele Detail
Symbol: Dmbt1tm1Kumc
Name: deleted in malignant brain tumors 1; targeted mutation 1, Robert C De Lisle
MGI ID: MGI:3514149
Gene: Dmbt1  Location: Chr7:131032053-131121630 bp, + strand  Genetic Position: Chr7, 73.2 cM, cytoband F4
Germline Transmission:  Earliest citation of germline transmission: J:132597
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe first exon and 300 bp of the first intron were replaced by a cassette composed of a GFP cassette inserted downstream of the TATA box in such a way that the GFP start codon replaced that of the endogenous gene as well as a PGK neomycin gene in reverse orientation. Lack of expression was confirmed by QRT-PCR and Western blot analysis. No GFP protein expression or mRNA was detected. (J:132597)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dmbt1 Mutation:  55 strains or lines available
Original:  J:132597 De Lisle RC, et al., Effects of Muclin (Dmbt1) deficiency on the gastrointestinal system. Am J Physiol Gastrointest Liver Physiol. 2008 Mar;294(3):G717-27
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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