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QTL Variant Detail
QTL variant: Fmgty9C3H/HeJ
Name: femur geometry 9; C3H/HeJ
MGI ID: MGI:3513000
QTL: Fmgty9  Location: unknown  Genetic Position: Chr11, cM position of peak correlated region/allele: 16.31 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Strain of Specimen:  C3H/HeJ
Allele Type:    QTL
Mutation:    Undefined
    This allele confers increased cortical thickness compared to DBA/2J. (J:94352)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures

Mapping and Phenotype information for this QTL, its variants and associated markers


487 animals from a heterogeneous stock designated UM-HET3 were analyzed for bone (femur) geometry traits. UM-HET3 is derived from a cross between (BALB/cJ x C57BL/6J)F1 x (C3H/HeJ x DBA/2J)F1. 99 polymorphic markers at an average spacing of 15 cM - 20 cM were used in the genome scan. Nine geometric traits were evaluated for each femur.

Linkage to cortical thickness, minimum outer fiber length (MinOFL), average outer fiber length (AveOFL), shape factor (SF), and medial/lateral axis bending moment of inertia (Iml) map to 16 cM on mouse Chromosome 11 near D11Mit83. This locus is designated Fmgty9. C57BL/6J-derived alleles confer increased SF, Iml, AveOFL, and MinOFL compared to BALB/cJ-derived alleles. C3H/HeJ-derived alleles confer increased cortical thickness compared to DBA/2J-derived alleles.

Original:  J:94352 Volkman SK, et al., Quantitative trait loci for femoral size and shape in a genetically heterogeneous mouse population. J Bone Miner Res. 2003 Aug;18(8):1497-505
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
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