Fmgty8^C3H/HeJ
QTL Variant Detail

Summary

• QTL variant: Fmgty8^C3H/HeJ
• Name: femur geometry 8; C3H/HeJ
• MGI ID: MGI:3512996
• QTL: Fmgty8 Location: unknown Genetic Position: Chr9, cM position of peak correlated region/allele: 48.27 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C3H/HeJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased minimum outer fiber length (MinOFL) compared to DBA/2J. (J:94352)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:94352

487 animals from a heterogeneous stock designated UM-HET3 were analyzed for bone (femur) geometry traits. UM-HET3 is derived from a cross between (BALB/cJ x C57BL/6J)F1 x (C3H/HeJ x DBA/2J)F1. 99 polymorphic markers at an average spacing of 15 cM - 20 cM were used in the genome scan. Nine geometric traits were evaluated for each femur.

Linkage to minimum outer fiber length (MinOFL) mapped to 48 cM on mouse Chromosome 9 near D9Mit110. This locus is designated Fmgty8. C3H/HeJ-derived alleles confer increased MinOFL compared to DBA/2J-derived alleles.

References

• Original: J:94352 Volkman SK, et al., Quantitative trait loci for femoral size and shape in a genetically heterogeneous mouse population. J Bone Miner Res. 2003 Aug;18(8):1497-505
• All: 1 reference(s)