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Fmgty2C3H/HeJ
QTL Variant Detail
Nomenclature
QTL variant: Fmgty2C3H/HeJ
Name: femur geometry 2; C3H/HeJ
MGI ID: MGI:3512978
QTL: Fmgty2  Location: unknown  Genetic Position: Chr3, cM position of peak correlated region/allele: 4.85 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Variant
origin
Strain of Specimen:  C3H/HeJ
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers increased cross sectional area compared to DBA/2J. (J:94352)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:94352

487 animals from a heterogeneous stock designated UM-HET3 were analyzed for bone (femur) geometry traits. UM-HET3 is derived from a cross between (BALB/cJ x C57BL/6J)F1 x (C3H/HeJ x DBA/2J)F1. 99 polymorphic markers at an average spacing of 15 cM - 20 cM were used in the genome scan. Nine geometric traits were evaluated for each femur.

Linkage to cross sectional area (CSA) mapped to 4.6 cM on mouse Chromosome 3 near D3Mit62. This locus is designated Fmgty2. C3H/HeJ-derived alleles confer increase CSA compared to DBA/2J-derived alleles.

References
Original:  J:94352 Volkman SK, et al., Quantitative trait loci for femoral size and shape in a genetically heterogeneous mouse population. J Bone Miner Res. 2003 Aug;18(8):1497-505
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory