Gabbr1^tm2Bet
Targeted Allele Detail

Summary

• Symbol: Gabbr1^tm2Bet
• Name: gamma-aminobutyric acid type B receptor subunit 1; targeted mutation 2, Bernhard Bettler
• MGI ID: MGI:3512742
• Synonyms: GABAB(1)^lox511, GABAB1R^lox511, Lox GABAB1
• Gene: Gabbr1 Location: Chr17:37356888-37385197 bp, + strand Genetic Position: Chr17, 19.16 cM
• Alliance: Gabbr1^tm2Bet page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94234
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: BALB/c

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to flank exons 7 and 8 with lox511 sites and to insert a floxed PGK-neo. Transfection of ES cells with a Cre plasmid removed the PGK-neo. Immunoblot of brain extracts from mutants showed that wild-type protein was expressed. (J:94234)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gabbr1 Mutation: 71 strains or lines available

References

• Original: J:94234 Haller C, et al., Floxed allele for conditional inactivation of the GABA(B(1)) gene. Genesis. 2004 Nov;40(3):125-30
• All: 20 reference(s)