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Targeted Allele Detail
Symbol: Il4tm2Rao
Name: interleukin 4; targeted mutation 2, Anjana Rao
MGI ID: MGI:3512141
Synonyms: HS IV-
Gene: Il4  Location: Chr11:53612460-53618665 bp, - strand  Genetic Position: Chr11, 31.97 cM
Germline Transmission:  Earliest citation of germline transmission: J:94039
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Modified regulatory region, Null/knockout)
Mutation:    Disruption caused by insertion of vector
Mutation detailsA loxP flanked neo replaced DNase I hypersensitivity site IV (HS IV). Transient Cre recombinase expression removed the cassette in ES cells. DNase hypersensitivity analysis of mutant cells showed a loss of HS IV, but no disruption of the other hypersensitivity sites. (J:94039)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Il4 Mutation:  29 strains or lines available
Original:  J:94039 Ansel KM, et al., Deletion of a conserved Il4 silencer impairs T helper type 1-mediated immunity. Nat Immunol. 2004 Dec;5(12):1251-9
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory