Phenotypes associated with this allele

• Allele Symbol: Rr169^tm2Rao
• Allele Name: targeted mutation 2, Anjana Rao
• Allele ID: MGI:3512141
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rr169^tm2Rao/Rr169^tm2Rao	involves: 129S6/SvEvTac * C57BL/6J	MGI:3513813
ht2	Rr169^tm2Rao/Rr169^+	involves: 129S6/SvEvTac * C57BL/6J	MGI:3513821

Genotype
MGI:3513813

hm1

• Allelic Composition: Rr169^tm2Rao/Rr169^tm2Rao
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal T-helper 1 cell differentiation ( J:94039 )

• conditions that normally produce mostly T helper 1 cells produce more T helper 2 cells and cells that abnormally produce both IFN-gamma and Il4

immune system

abnormal T-helper 1 cell differentiation ( J:94039 )

• conditions that normally produce mostly T helper 1 cells produce more T helper 2 cells and cells that abnormally produce both IFN-gamma and Il4

increased susceptibility to parasitic infection ( J:94039 )

• after infection with L. major increased footpad swelling and parasite burden is seen

Genotype
MGI:3513821

ht2

• Allelic Composition: Rr169^tm2Rao/Rr169⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

hematopoietic system

abnormal T-helper 1 cell differentiation ( J:94039 )

• conditions that normally produce mostly T helper 1 cells produce more T helper 2 cells and cells that abnormally produce both IFN-gamma and Il4, this phenotype is intermediate between homozygotes and wild-type

immune system

abnormal T-helper 1 cell differentiation ( J:94039 )

• conditions that normally produce mostly T helper 1 cells produce more T helper 2 cells and cells that abnormally produce both IFN-gamma and Il4, this phenotype is intermediate between homozygotes and wild-type