About   Help   FAQ
Targeted Allele Detail
Symbol: Prkar1atm1.2Lsk
Name: protein kinase, cAMP dependent regulatory, type I, alpha; targeted mutation 1.2, Lawrence Kirschner
MGI ID: MGI:3512112
Synonyms: Prkar1aloxP
Gene: Prkar1a  Location: Chr11:109540231-109560482 bp, + strand  Genetic Position: Chr11, 72.33 cM
Prkar1a heterozygosity accelerates osteosarcoma development in Tg(Bglap2-TAg)1Rkho/0 mice

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:98799
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP site was inserted between exons 1b and 1c and a floxed neomycin resistance cassette was inserted in intron 2. Mice carrying the floxed neomycin resistance cassette were bred to EIIa-cre mice, resulting in removal of the cassette with lox P sites remaining between exons 1b and 1c and in intron 2. (J:98799)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Prkar1a Mutation:  16 strains or lines available
Original:  J:98799 Kirschner LS, et al., A mouse model for the Carney complex tumor syndrome develops neoplasia in cyclic AMP-responsive tissues. Cancer Res. 2005 Jun 1;65(11):4506-14
All:  28 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.19
The Jackson Laboratory