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Thoc1tm1Dwg
Targeted Allele Detail
Nomenclature
Symbol: Thoc1tm1Dwg
Name: THO complex 1; Targeted mutation 1, David W Goodrich
MGI ID: MGI:3512076
Synonyms: Thoc1-
Gene: Thoc1  Location: Chr18:9958180-9995484 bp, + strand  Genetic Position: Chr18, 4.91 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:109614
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 2-8 were replaced with a PGKneo selection cassette. The deletion also causes a frame shift, preventing translation of exons 9-21. Absence of protein product was confirmed by Western blot analysis and QRT-PCR. (J:109614)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 4 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Thoc1 Mutation:  23 strains or lines available
References
Original:  J:109614 Wang X, et al., Thoc1/Hpr1/p84 is essential for early embryonic development in the mouse. Mol Cell Biol. 2006 Jun;26(11):4362-7
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory