Phenotypes associated with this allele

• Allele Symbol: Thoc1^tm1Dwg
• Allele Name: targeted mutation 1, David W Goodrich
• Allele ID: MGI:3512076
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Thoc1^tm1Dwg/Thoc1^tm1Dwg	involves: 129S4/SvJae	MGI:3652589
ht2	Thoc1^tm1Dwg/Thoc1^tm2Dwg	involves: 129S4/SvJae * C57BL/6J	MGI:3698530

Genotype
MGI:3652589

hm1

• Allelic Composition: Thoc1^tm1Dwg/Thoc1^tm1Dwg
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality at implantation, complete penetrance ( J:109614 )

• no post-implantation homozygotes are detected at E8.5-11.5, however, expected Mendelian numbers of homozygous blastocysts are recovered at E3.5 suggesting lethality around the time of implantation

embryo

increased embryonic tissue cell apoptosis ( J:109614 )

• after E3.5, null embryos show increased cellular apoptosis and loss of cell viability

failure of blastocyst to hatch from the zona pellucida ( J:109614 )

• most embryos fail to hatch from the zona pellucida

absent inner cell mass ( J:109614 )

• null embryos in culture cannot produce viable blastocyst outgrowths as cells of the inner cell mass are lacking

cellular

increased embryonic tissue cell apoptosis ( J:109614 )

• after E3.5, null embryos show increased cellular apoptosis and loss of cell viability

Genotype
MGI:3698530

ht2

• Allelic Composition: Thoc1^tm1Dwg/Thoc1^tm2Dwg
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:117869 )

• embryos are detected at E13.5 but no viable neonates are recovered indicating lethality after E13.5 but before birth

embryo

decreased embryo size ( J:117869 )

growth/size/body

decreased embryo size ( J:117869 )