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Pbx3tm1Mlc
Targeted Allele Detail
Nomenclature
Symbol: Pbx3tm1Mlc
Name: pre B cell leukemia homeobox 3; targeted mutation 1, Michael L Cleary
MGI ID: MGI:3510441
Synonyms: Pbx3-
Gene: Pbx3  Location: Chr2:34171457-34373142 bp, - strand  Genetic Position: Chr2, 22.84 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:93761
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 3 was replaced with a neomycin resistance gene in opposite transcription orientation. The deletion created an early frame-shift mutation that caused termination of the reading frame upstream of its dimerization and DNA binding domains. Western blot indicated a lack of protein in brains of mutants. (J:93761)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pbx3 Mutation:  12 strains or lines available
References
Original:  J:93761 Rhee JW, et al., Pbx3 deficiency results in central hypoventilation. Am J Pathol. 2004 Oct;165(4):1343-50
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/24/2015
MGI 5.21
The Jackson Laboratory