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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pbx3tm1Mlc
targeted mutation 1, Michael L Cleary
MGI:3510441
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pbx3tm1Mlc/Pbx3tm1Mlc involves: C57BL/6 MGI:3510705
cn2
 		Pbx1tm1Koss/Pbx1tm1Koss
Pbx3tm1Mlc/Pbx3+
Foxg1tm1(cre)Skm/Foxg1+ 		involves: 129P2/OlaHsd MGI:5305924
cn3
 		Pbx1tm1Koss/Pbx1tm1Koss
Pbx3tm1Mlc/Pbx3+
Tg(Tcfap2a-cre)1Will/0 		involves: 129P2/OlaHsd MGI:5305926
cx4
 		Pbx1tm1Mlc/Pbx1tm1Mlc
Pbx3tm1Mlc/Pbx3+ 		involves: 129S6/SvEvTac MGI:5305929
cx5
 		Pbx1tm1Mlc/Pbx1+
Pbx2tm1Mlc/Pbx2+
Pbx3tm1Mlc/Pbx3+ 		involves: 129S6/SvEvTac MGI:5305931


Genotype
MGI:3510705
hm1
Allelic
Composition		 Pbx3tm1Mlc/Pbx3tm1Mlc
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pbx3tm1Mlc mutation (0 available); any Pbx3 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:93761 )
• homozygotes are born alive but die within a few hours of birth

homeostasis/metabolism

respiratory system
hypoventilation ( J:93761 )
• irregular tidal volumes and reduced respiratory frequency are seen
respiratory failure ( J:93761 )
• the lungs are not inflated at the time of death

nervous system
abnormal somatic nervous system physiology ( J:93761 )
• C4 ventral nerve inspiratory activity shows higher frequency but lower amplitude bursts of motoneuronal output




Genotype
MGI:5305924
cn2
Allelic
Composition		 Pbx1tm1Koss/Pbx1tm1Koss
Pbx3tm1Mlc/Pbx3+
Foxg1tm1(cre)Skm/Foxg1+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxg1tm1(cre)Skm mutation (2 available); any Foxg1 mutation (28 available)
Pbx1tm1Koss mutation (0 available); any Pbx1 mutation (40 available)
Pbx3tm1Mlc mutation (0 available); any Pbx3 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
cleft upper lip ( J:178316 )
• cleft lip and/or palate
cleft palate ( J:178316 )
• cleft lip and/or palate

digestive/alimentary system
cleft palate ( J:178316 )
• cleft lip and/or palate

growth/size/body
cleft upper lip ( J:178316 )
• cleft lip and/or palate
cleft palate ( J:178316 )
• cleft lip and/or palate




Genotype
MGI:5305926
cn3
Allelic
Composition		 Pbx1tm1Koss/Pbx1tm1Koss
Pbx3tm1Mlc/Pbx3+
Tg(Tcfap2a-cre)1Will/0
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pbx1tm1Koss mutation (0 available); any Pbx1 mutation (40 available)
Pbx3tm1Mlc mutation (0 available); any Pbx3 mutation (35 available)
Tg(Tcfap2a-cre)1Will mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
cleft upper lip ( J:178316 )
• cleft lip and/or palate
cleft palate ( J:178316 )
• cleft lip and/or palate

digestive/alimentary system
cleft palate ( J:178316 )
• cleft lip and/or palate

growth/size/body
cleft upper lip ( J:178316 )
• cleft lip and/or palate
cleft palate ( J:178316 )
• cleft lip and/or palate




Genotype
MGI:5305929
cx4
Allelic
Composition		 Pbx1tm1Mlc/Pbx1tm1Mlc
Pbx3tm1Mlc/Pbx3+
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pbx1tm1Mlc mutation (0 available); any Pbx1 mutation (40 available)
Pbx3tm1Mlc mutation (0 available); any Pbx3 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
micrognathia ( J:178316 )
• bilateral or unilateral
bilateral cleft upper lip ( J:178316 )
• bilateral or unilateral cleft lip and/or palate
unilateral cleft upper lip ( J:178316 )
• bilateral or unilateral cleft lip and/or palate
cleft palate ( J:178316 )
• bilateral or unilateral cleft lip and/or palate
small snout ( J:178316 )
• small nose

homeostasis/metabolism
edema ( J:178316 )
• head edema with E13.5

skeleton
micrognathia ( J:178316 )
• bilateral or unilateral

digestive/alimentary system
cleft palate ( J:178316 )
• bilateral or unilateral cleft lip and/or palate

growth/size/body
bilateral cleft upper lip ( J:178316 )
• bilateral or unilateral cleft lip and/or palate
unilateral cleft upper lip ( J:178316 )
• bilateral or unilateral cleft lip and/or palate
cleft palate ( J:178316 )
• bilateral or unilateral cleft lip and/or palate
bilateral cleft palate ( J:178316 )
unilateral cleft palate ( J:178316 )
tongue hypoplasia ( J:178316 )
small snout ( J:178316 )
• small nose




Genotype
MGI:5305931
cx5
Allelic
Composition		 Pbx1tm1Mlc/Pbx1+
Pbx2tm1Mlc/Pbx2+
Pbx3tm1Mlc/Pbx3+
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pbx1tm1Mlc mutation (0 available); any Pbx1 mutation (40 available)
Pbx2tm1Mlc mutation (0 available); any Pbx2 mutation (14 available)
Pbx3tm1Mlc mutation (0 available); any Pbx3 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial

digestive/alimentary system

mortality/aging

growth/size/body
cleft palate ( J:178316 )




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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory