All Phenotypes Pbx3<tm1Mlc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pbx3^tm1Mlc
targeted mutation 1, Michael L Cleary
MGI:3510441

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pbx3^tm1Mlc/Pbx3^tm1Mlc	involves: C57BL/6	MGI:3510705
cn2	Pbx1^tm1Koss/Pbx1^tm1Koss Pbx3^tm1Mlc/Pbx3⁺ Foxg1^tm1(cre)Skm/Foxg1⁺	involves: 129P2/OlaHsd	MGI:5305924
cn3	Pbx1^tm1Koss/Pbx1^tm1Koss Pbx3^tm1Mlc/Pbx3⁺ Tg(Tcfap2a-cre)1Will/0	involves: 129P2/OlaHsd	MGI:5305926
cx4	Pbx1^tm1Mlc/Pbx1⁺ Pbx2^tm1Mlc/Pbx2⁺ Pbx3^tm1Mlc/Pbx3⁺	involves: 129S6/SvEvTac	MGI:5305931
cx5	Pbx1^tm1Mlc/Pbx1^tm1Mlc Pbx3^tm1Mlc/Pbx3⁺	involves: 129S6/SvEvTac	MGI:5305929

Allelic Composition	Pbx3^tm1Mlc/Pbx3^tm1Mlc
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pbx3^tm1Mlc mutation (0 available); any Pbx3 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:93761 )

• homozygotes are born alive but die within a few hours of birth

homeostasis/metabolism

cyanosis ( J:93761 )

respiratory system

hypoventilation ( J:93761 )

• irregular tidal volumes and reduced respiratory frequency are seen

respiratory failure ( J:93761 )

• the lungs are not inflated at the time of death

nervous system

abnormal somatic nervous system physiology ( J:93761 )

• C4 ventral nerve inspiratory activity shows higher frequency but lower amplitude bursts of motoneuronal output

Allelic Composition	Pbx1^tm1Koss/Pbx1^tm1Koss Pbx3^tm1Mlc/Pbx3⁺ Foxg1^tm1(cre)Skm/Foxg1⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxg1^tm1(cre)Skm mutation (2 available); any Foxg1 mutation (31 available)
Pbx1^tm1Koss mutation (0 available); any Pbx1 mutation (38 available)
Pbx3^tm1Mlc mutation (0 available); any Pbx3 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

cleft upper lip ( J:178316 )

• cleft lip and/or palate

cleft palate ( J:178316 )

• cleft lip and/or palate

digestive/alimentary system

cleft palate ( J:178316 )

• cleft lip and/or palate

growth/size/body

cleft upper lip ( J:178316 )

• cleft lip and/or palate

cleft palate ( J:178316 )

• cleft lip and/or palate

Allelic Composition	Pbx1^tm1Koss/Pbx1^tm1Koss Pbx3^tm1Mlc/Pbx3⁺ Tg(Tcfap2a-cre)1Will/0
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pbx1^tm1Koss mutation (0 available); any Pbx1 mutation (38 available)
Pbx3^tm1Mlc mutation (0 available); any Pbx3 mutation (37 available)
Tg(Tcfap2a-cre)1Will mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

cleft upper lip ( J:178316 )

• cleft lip and/or palate

cleft palate ( J:178316 )

• cleft lip and/or palate

digestive/alimentary system

cleft palate ( J:178316 )

• cleft lip and/or palate

growth/size/body

cleft upper lip ( J:178316 )

• cleft lip and/or palate

cleft palate ( J:178316 )

• cleft lip and/or palate

Allelic Composition	Pbx1^tm1Mlc/Pbx1⁺ Pbx2^tm1Mlc/Pbx2⁺ Pbx3^tm1Mlc/Pbx3⁺
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pbx1^tm1Mlc mutation (0 available); any Pbx1 mutation (38 available)
Pbx2^tm1Mlc mutation (0 available); any Pbx2 mutation (12 available)
Pbx3^tm1Mlc mutation (0 available); any Pbx3 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

cleft palate ( J:178316 )

digestive/alimentary system

cleft palate ( J:178316 )

mortality/aging

neonatal lethality, complete penetrance ( J:178316 )

growth/size/body

cleft palate ( J:178316 )

Allelic Composition	Pbx1^tm1Mlc/Pbx1^tm1Mlc Pbx3^tm1Mlc/Pbx3⁺
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pbx1^tm1Mlc mutation (0 available); any Pbx1 mutation (38 available)
Pbx3^tm1Mlc mutation (0 available); any Pbx3 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

micrognathia ( J:178316 )

• bilateral or unilateral

bilateral cleft upper lip ( J:178316 )

• bilateral or unilateral cleft lip and/or palate

unilateral cleft upper lip ( J:178316 )

• bilateral or unilateral cleft lip and/or palate

cleft palate ( J:178316 )

• bilateral or unilateral cleft lip and/or palate

bilateral cleft palate ( J:178316 )

unilateral cleft palate ( J:178316 )

tongue hypoplasia ( J:178316 )

small snout ( J:178316 )

• small nose

homeostasis/metabolism

edema ( J:178316 )

• head edema with E13.5

skeleton

micrognathia ( J:178316 )

• bilateral or unilateral

digestive/alimentary system

cleft palate ( J:178316 )

• bilateral or unilateral cleft lip and/or palate

bilateral cleft palate ( J:178316 )

unilateral cleft palate ( J:178316 )

tongue hypoplasia ( J:178316 )

growth/size/body

micrognathia ( J:178316 )

• bilateral or unilateral

bilateral cleft upper lip ( J:178316 )

• bilateral or unilateral cleft lip and/or palate

unilateral cleft upper lip ( J:178316 )

• bilateral or unilateral cleft lip and/or palate

cleft palate ( J:178316 )

• bilateral or unilateral cleft lip and/or palate

bilateral cleft palate ( J:178316 )

unilateral cleft palate ( J:178316 )

tongue hypoplasia ( J:178316 )

small snout ( J:178316 )

• small nose

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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