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Mybtm1Epr
Targeted Allele Detail
Nomenclature
Symbol: Mybtm1Epr
Name: myeloblastosis oncogene; targeted mutation 1, E Premkumar Reddy
MGI ID: MGI:3497746
Synonyms: mybF
Gene: Myb  Location: Chr10:21124935-21160984 bp, - strand  Genetic Position: Chr10, 9.75 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:93481
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsExon 6 encoding the high-affinity DNA-binding domain was flanked with loxP sites by homologous recombination of a construct that also contained a PGK-neo and thymidine kinase selection markers. The PGK-neo-thymidine kinase marker was excised by transient transfection of properly targeted ES cells with a cre-expressing plasmid and left exon 6 flanked by loxP sites. (J:93481)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Myb Mutation:  12 strains or lines available
References
Original:  J:93481 Lieu YK, et al., Requirement of c-myb in T cell development and in mature T cell function. Proc Natl Acad Sci U S A. 2004 Nov 12;101(41):14853-8
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory