All Phenotypes Myb<tm1Epr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Myb^tm1Epr
targeted mutation 1, E Premkumar Reddy
MGI:3497746

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Myb^tm1Epr/Myb^tm1Epr Tg(Lck-cre)548Jxm/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	MGI:3511178
cn2	Myb^tm1Epr/Myb^tm1Epr Tg(Cd4-cre)1Cwi/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2	MGI:3511179

Allelic Composition	Myb^tm1Epr/Myb^tm1Epr Tg(Lck-cre)548Jxm/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myb^tm1Epr mutation (1 available); any Myb mutation (56 available)
Tg(Lck-cre)548Jxm mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

thymus hypoplasia ( J:93481 )

• cellularity of the thymus is reduced to 11% of controls

abnormal T cell differentiation ( J:93481 )

abnormal double-negative T cell morphology ( J:93481 )

• thymocytes accumulate at the DN3 stage

• reduced numbers of cells at the DN4 stage

decreased double-positive T cell number ( J:93481 )

• double positive cell population reduced to 62% of normal

immune system

thymus hypoplasia ( J:93481 )

• cellularity of the thymus is reduced to 11% of controls

abnormal T cell differentiation ( J:93481 )

abnormal double-negative T cell morphology ( J:93481 )

• thymocytes accumulate at the DN3 stage

• reduced numbers of cells at the DN4 stage

decreased double-positive T cell number ( J:93481 )

• double positive cell population reduced to 62% of normal

endocrine/exocrine glands

thymus hypoplasia ( J:93481 )

• cellularity of the thymus is reduced to 11% of controls

Allelic Composition	Myb^tm1Epr/Myb^tm1Epr Tg(Cd4-cre)1Cwi/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myb^tm1Epr mutation (1 available); any Myb mutation (56 available)
Tg(Cd4-cre)1Cwi mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

thymus hypoplasia ( J:93481 )

• cellularity of the thymus is reduced by 17%

abnormal T cell differentiation ( J:93481 )

decreased double-positive T cell number ( J:93481 )

• double positive cell proportion is similar to controls but absolute numbers are reduced by 17%

decreased CD4-positive, alpha-beta T cell number ( J:93481 )

• CD4+ cell numbers are reduced

increased CD8-positive, alpha-beta T cell number ( J:93481 )

• CD8+ cell numbers are increased

immune system

thymus hypoplasia ( J:93481 )

• cellularity of the thymus is reduced by 17%

abnormal T cell differentiation ( J:93481 )

decreased double-positive T cell number ( J:93481 )

• double positive cell proportion is similar to controls but absolute numbers are reduced by 17%

decreased CD4-positive, alpha-beta T cell number ( J:93481 )

• CD4+ cell numbers are reduced

increased CD8-positive, alpha-beta T cell number ( J:93481 )

• CD8+ cell numbers are increased

endocrine/exocrine glands

thymus hypoplasia ( J:93481 )

• cellularity of the thymus is reduced by 17%

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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