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Sptbn4tm1Msol
Targeted Allele Detail
Nomenclature
Symbol: Sptbn4tm1Msol
Name: spectrin beta, non-erythrocytic 4; targeted mutation 1, Michele Solimena
MGI ID: MGI:3497744
Synonyms: betaIVepsilon1-
Gene: Sptbn4  Location: Chr7:27356383-27447686 bp, - strand  Genetic Position: Chr7, 15.88 cM, cytoband A3
Nodes of Ranvier abnormalities in Sptbn4tm1Msol/Sptbn4tm1Msol mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:93411
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 2 of the epsilon 1 isoform, encoding the first methionine, was replaced by a neomycin resistance gene in opposite transcriptional orientation to the gene via homologous recombination. Western and immunofluorescence analysis confirmed the absence of protein in adult brain and sciatic nerve. (J:93411)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sptbn4 Mutation:  77 strains or lines available
References
Original:  J:93411 Lacas-Gervais S, et al., BetaIVSigma1 spectrin stabilizes the nodes of Ranvier and axon initial segments. J Cell Biol. 2004 Oct 27;166(7):983-90
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/14/2017
MGI 6.08
The Jackson Laboratory