Phenotypes associated with this allele

• Allele Symbol: Sptbn4^tm1Msol
• Allele Name: targeted mutation 1, Michele Solimena
• Allele ID: MGI:3497744
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sptbn4^tm1Msol/Sptbn4^tm1Msol	involves: C57BL/6	MGI:3510444

Genotype
MGI:3510444

hm1

• Allelic Composition: Sptbn4^tm1Msol/Sptbn4^tm1Msol
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Nodes of Ranvier abnormalities in Sptbn4^tm1Msol/Sptbn4^tm1Msol mice

behavior/neurological

tremors ( J:93411 )

dysmetria ( J:93411 )

• mild dysmetria is seen

abnormal gait ( J:93411 )

• a clumsy gait with dragging of the hind limbs is seen

growth/size/body

decreased body weight ( J:93411 )

• homozygotes are smaller at 3 weeks of age

hearing/vestibular/ear

abnormal auditory brainstem response ( J:93411 )

• auditory brainstem responses revealed increased latency of auditory evoked potentials and auditory neural fatigue without alteration in auditory thresholds

vision/eye

abnormal optic nerve morphology ( J:93411 )

• the nodes of Ranvier are longer and swollen

nervous system

abnormal cerebellum morphology ( J:93411 )

• the width and length of the nodes of Ranvier are increased while the length of paranodes is decreased

abnormal optic nerve morphology ( J:93411 )

• the nodes of Ranvier are longer and swollen

abnormal sciatic nerve morphology ( J:93411 )

• the nodes of Ranvier are shorter, larger, and geometrically less regular