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Hipk2tm1Ejh
Targeted Allele Detail
Nomenclature
Symbol: Hipk2tm1Ejh
Name: homeodomain interacting protein kinase 2; targeted mutation 1, Eric J Huang
MGI ID: MGI:3487301
Gene: Hipk2  Location: Chr6:38694390-38876165 bp, - strand  Genetic Position: Chr6, 17.85 cM, cytoband B
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:93311
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsLacZ and PGK-neo replaced exon 3 (the first coding exon) and were inserted in frame with the first ATG via homologous recombination. Northern analysis and RT-PCR confirmed the absence of mRNA in MEFs and trigeminal ganglia, respectively. Beta-galactosidase was expressed in developing trigeminal ganglion and dorsal root ganglion. (J:93311)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hipk2 Mutation:  9 strains or lines available
References
Original:  J:93311 Wiggins AK, et al., Interaction of Brn3a and HIPK2 mediates transcriptional repression of sensory neuron survival. J Cell Biol. 2004 Nov 25;167(2):257-67
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/30/2020
MGI 6.15
The Jackson Laboratory