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Nhlh2tm1Thbr
Targeted Allele Detail
Nomenclature
Symbol: Nhlh2tm1Thbr
Name: nescient helix loop helix 2; targeted mutation 1, Thomas Braun
MGI ID: MGI:3057284
Synonyms: NSCL-2-, NSCL-2lacZ
Gene: Nhlh2  Location: Chr3:102010111-102015492 bp, + strand  Genetic Position: Chr3, 44.3 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:93303
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn IRES-lacZ-neomycin resistance cassette replaced the first and part of the second exon including parts of the DNA binding bHLH region, and placed lacZ under control of endogenous transcriptional elements. Beta-galactosidase was expresssed under the control of the endogenous promoter. (J:93303)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 20 assay results
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nhlh2 Mutation:  4 strains or lines available
References
Original:  J:93303 Kruger M, et al., NSCL-1 and NSCL-2 synergistically determine the fate of GnRH-1 neurons and control necdin gene expression. EMBO J. 2004 Nov 27;23(21):4353-64
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/30/2020
MGI 6.15
The Jackson Laboratory