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Srgntm1Mabr
Targeted Allele Detail
Nomenclature
Symbol: Srgntm1Mabr
Name: serglycin; targeted mutation 1, Magnus Abrink
MGI ID: MGI:3057187
Synonyms: Sg-
Gene: Srgn  Location: Chr10:62493833-62527451 bp, - strand  Genetic Position: Chr10, 32.42 cM, cytoband B4
Srgntm1Mabr/Srgntm1Mabr peritoneal mast cells contain large empty vesicles

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:93338
Parent Cell Line:  GSI-1 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1 and the regulatory sequences were replaced with a neomycin resistance cassette in reverse orientation to transcription. RT-PCR of spleens from mutant mice indicated a lack of protein. (J:93338)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Srgn Mutation:  9 strains or lines available
References
Original:  J:93338 Abrink M, et al., Serglycin is essential for maturation of mast cell secretory granule. J Biol Chem. 2004 Oct 24;279(39):40897-905
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/05/2017
MGI 6.11
The Jackson Laboratory