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Tg(Igh-6/Igh-V281)3Jwt
Transgene Detail
Nomenclature
Symbol: Tg(Igh-6/Igh-V281)3Jwt
Name: transgene insertion 3, James W Thomas
MGI ID: MGI:3056939
Synonyms: 281HC, H125.gl, VH281, VH281Tg
Transgene: Tg(Igh-6/Igh-V281)3Jwt  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Igh-6/Igh-V281)3Jwt expresses 2 genes
 
Mutation detailsThe construct for Tg(Igh-6/Igh-V281)3Jwt has a germ line reversion encoding D at residue 49 (from G)and another encoding V (from E) at residue 56. The transgene encodes an IgMa constant region with a variable region nearly identical to that of the BALB/c IgG1 mouse anti-human insulin monoclonal antibody, mAb125, (from the American Type Culture Collection) but lacking the high affinity specificity for insulin. (J:91865)
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:91865 Hulbert C, et al., B cell specificity contributes to the outcome of diabetes in nonobese diabetic mice. J Immunol. 2001 Nov 15;167(10):5535-8
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/17/2015
MGI 5.21
The Jackson Laboratory