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Targeted Allele Detail
Symbol: Tnnt2tm1Mmto
Name: troponin T2, cardiac; targeted mutation 1, Sachio Morimoto
MGI ID: MGI:3055296
Synonyms: cTnT-
Gene: Tnnt2  Location: Chr1:135836354-135852260 bp, + strand  Genetic Position: Chr1, 59.32 cM
Germline Transmission:  Earliest citation of germline transmission: J:141967
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA floxed neo cassette was inserted between exons 12 and 13 and an exon 13 containing a deletion of three base pairs that results in the deletion of lysine at position 210 (K210) were inserted via homologous recombination. Immunohistochemical and western blot analysis indicate absence of protein expression in hearts from homozygous mice. (J:141967)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tnnt2 Mutation:  39 strains or lines available
Original:  J:141967 Nishii K, et al., Targeted disruption of the cardiac troponin T gene causes sarcomere disassembly and defects in heartbeat within the early mouse embryo. Dev Biol. 2008 Oct 1;322(1):65-73
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory