Phenotypes associated with this allele

• Allele Symbol: Tnnt2^tm1Mmto
• Allele Name: targeted mutation 1, Sachio Morimoto
• Allele ID: MGI:3055296
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tnnt2^tm1Mmto/Tnnt2^tm1Mmto	involves: 129S/SvEv	MGI:3821722
ht2	Tnnt2^tm1Mmto/Tnnt2^+	involves: 129S/SvEv	MGI:3821723

Genotype
MGI:3821722

hm1

• Allelic Composition: Tnnt2^tm1Mmto/Tnnt2^tm1Mmto
• Genetic Background: involves: 129S/SvEv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:141967 )

• die between E10 and E11.5

cardiovascular system

absent atrioventricular cushions ( J:141967 )

• at E9.25

failure of heart looping ( J:141967 )

• at E9.25 all sections of the heart remain in the same plane

dilated heart ( J:141967 )

• dilated heart containing fewer cells

absent heartbeat ( J:141967 )

• embryos never have a heartbeat

muscle

abnormal sarcomere morphology ( J:141967 )

• sarcomeres lack the normal hexagonal structure and instead the filaments are dispersed throughout the cytoplasm

embryo

decreased embryo size ( J:141967 )

abnormal embryonic tissue morphology ( J:141967 )

• embryos are more translucent and appear to contain fewer cells

growth/size/body

decreased embryo size ( J:141967 )

Genotype
MGI:3821723

ht2

• Allelic Composition: Tnnt2^tm1Mmto/Tnnt2⁺
• Genetic Background: involves: 129S/SvEv

normal phenotype

no abnormal phenotype detected ( J:141967 )

• despite most causative mutations in TNNT2 resulting in cardiomyopathy in humans being dominant, heterozygous mice are viable with normal heart structure and function

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	dilated cardiomyopathy 1D	DOID:0110426	OMIM:601494	J:141967