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Sobpjc-2J
Spontaneous Allele Detail
Nomenclature
Symbol: Sobpjc-2J
Name: sine oculis binding protein; Jackson circler 2 Jackson
MGI ID: MGI:3055292
Gene: Sobp  Location: Chr10:42878496-43050526 bp, - strand  Genetic Position: Chr10, 22.89 cM
Mutation
origin
Strain of Origin:  B6.129S2-Il6tm1Kopf/J
Mutation
description
Allele Type:    Spontaneous
Mutation:    Single point mutation
 
Mutation detailsThis spontaneous mutation, discovered in a production colony at The Jackson Laboratory, was shown to be allelic with the original Jackson circler mutation by failure of the two alleles to complement one another. A G-to-T transversion occurs at coding nucleotide position 1894 (c.1894G>T) that converts the glycine codon at amino acid residue 632 to a stop codon (p.G632*). The resulting protein is reduced in length by 28%. (J:113021, J:137716)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sobp Mutation:  25 strains or lines available
References
Original:  J:113021 Calderon A, et al., Cochlear developmental defect and background-dependent hearing thresholds in the Jackson circler (jc) mutant mouse. Hear Res. 2006 Nov;221(1-2):44-58
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory