About   Help   FAQ
Jam3tm1Rha
Targeted Allele Detail
Summary
Symbol: Jam3tm1Rha
Name: junction adhesion molecule 3; targeted mutation 1, Ralf H Adams
MGI ID: MGI:3055281
Synonyms: Jam-C-
Gene: Jam3  Location: Chr9:27008680-27066717 bp, - strand  Genetic Position: Chr9, 12.27 cM
Alliance: Jam3tm1Rha page
Small body size, severe hydrocephalus, and brain alterations in Jam3tm1Rha/Jam3tm1Rha mice

Show the 6 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:92665
Parent Cell Line:  E14K (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsES cells were transfected with a construct containing exons 4 and 5 flanked by loxP sites. The construct also contained an IRES-lacZ-pA cassette fused to the 5' end of exon 4 and a neomycin resistance cassette surrounded by Frt sites. This allele was generated by crossing mice carrying the floxed gene with mice carrying PGK-Cre and and a second strain of mice carrying the Flp transgene. Western blot analysis of E12.5 embryos did not detect protein. (J:92665)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 15 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Jam3 Mutation:  24 strains or lines available
References
Original:  J:92665 Gliki G, et al., Spermatid differentiation requires the assembly of a cell polarity complex downstream of junctional adhesion molecule-C. Nature. 2004 Sep 16;431(7006):320-4
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory