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Targeted Allele Detail
Symbol: Jam3tm1Rha
Name: junction adhesion molecule 3; targeted mutation 1, Ralf H Adams
MGI ID: MGI:3055281
Synonyms: Jam-C-
Gene: Jam3  Location: Chr9:27097384-27155421 bp, - strand  Genetic Position: Chr9, 12.27 cM
Small body size, severe hydrocephalus, and brain alterations in Jam3tm1Rha/Jam3tm1Rha mice

Show the 6 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:92665
Parent Cell Line:  E14K (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsES cells were transfected with a construct containing exons 4 and 5 flanked by loxP sites. The construct also contained an IRES-lacZ-pA cassette fused to the 5' end of exon 4 and a neomycin resistance cassette surrounded by Frt sites. This allele was generated by crossing mice carrying the floxed gene with mice carrying PGK-Cre and and a second strain of mice carrying the Flp transgene. Western blot analysis of E12.5 embryos did not detect protein. (J:92665)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 15 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Jam3 Mutation:  3 strains or lines available
Original:  J:92665 Gliki G, et al., Spermatid differentiation requires the assembly of a cell polarity complex downstream of junctional adhesion molecule-C. Nature. 2004 Sep 16;431(7006):320-4
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory