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Tnfaip3tm1Ama
Targeted Allele Detail
Nomenclature
Symbol: Tnfaip3tm1Ama
Name: tumor necrosis factor, alpha-induced protein 3; targeted mutation 1, Averil Ma
MGI ID: MGI:3055173
Synonyms: A20-
Gene: Tnfaip3  Location: Chr10:19000910-19015657 bp, - strand  Genetic Position: Chr10, 8.08 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:92931
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA PGK-neo in reverse transcription orientation replaced exons 1-4, encompassing the ATG initiation codon and residues 1-246. (J:92931)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tnfaip3 Mutation:  2 strains or lines available
References
Original:  J:92931 Lee EG, et al., Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice. Science. 2000 Sep 29;289(5488):2350-4
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory