Tg(KRT10BMP6)VI632Mbl
Transgene Detail

Nomenclature

• Symbol: Tg(KRT10BMP6)VI632Mbl
• Name: transgene insertion VI632, Manfred Blessing
• MGI ID: MGI:3054946
• Transgene: Tg(KRT10BMP6)VI632Mbl Location: unknown

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(KRT10BMP6)VI632Mbl expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Homolog in Mouse	Note
  Human	BMP6 (654)	Bmp6

• Mutation details: The transgene contains the human bone morphogenic protein 6 (BMP6) gene under the control of the bovine keratin 10 promoter. (J:36521)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Transgenic mice on an FVB background appear normal at birth, but begin to show skin abnormalities at about 6 days of age. Inflammatory lesions develop by 2-3 weeks of age. The skin condition progressively worsens and is characterized by hair loss, flaky skin, and nail abnormalities. As the transgene inserted into the Y Chromosome, only males are affected.

References

• Original: J:36521 Blessing M, et al., Overexpression of bone morphogenetic protein-6 (BMP-6) in the epidermis of transgenic mice: inhibition or stimulation of proliferation depending on the pattern of transgene expression and formation of psoriatic lesions. J Cell Biol. 1996 Oct;135(1):227-39
• All: 2 reference(s)