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Tg(KRT10BMP6)VI632Mbl
Transgene Detail
Nomenclature
Symbol: Tg(KRT10BMP6)VI632Mbl
Name: transgene insertion VI632, Manfred Blessing
MGI ID: MGI:3054946
Transgene: Tg(KRT10BMP6)VI632Mbl  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(KRT10BMP6)VI632Mbl expresses 1 gene
 
Mutation detailsThe transgene contains the human bone morphogenic protein 6 (BMP6) gene under the control of the bovine keratin 10 promoter. (J:36521)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Notes
Transgenic mice on an FVB background appear normal at birth, but begin to show skin abnormalities at about 6 days of age. Inflammatory lesions develop by 2-3 weeks of age. The skin condition progressively worsens and is characterized by hair loss, flaky skin, and nail abnormalities. As the transgene inserted into the Y Chromosome, only males are affected.
References
Original:  J:36521 Blessing M, et al., Overexpression of bone morphogenetic protein-6 (BMP-6) in the epidermis of transgenic mice: inhibition or stimulation of proliferation depending on the pattern of transgene expression and formation of psoriatic lesions. J Cell Biol. 1996 Oct;135(1):227-39
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory