Casr^Nuf
Chemically induced Allele Detail

Summary

• Symbol: Casr^Nuf
• Name: calcium-sensing receptor; nuclear flecks
• MGI ID: MGI:3054788
• Synonyms: iPMS-112, Nuf
• Gene: Casr Location: Chr16:36314058-36382503 bp, - strand Genetic Position: Chr16, 25.57 cM
• Alliance: Casr^Nuf page

Ectopic calcification and cataract formation in Casr^Nuf/Casr⁺ and Casr^Nuf/Casr^Nuf mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: (C3H/He x 102/El)F1

Mutation description

• Allele Type: Chemically induced (other)
• Mutation: Single point mutation
• Mutation details: This mutation was induced by treating a male mouse with isopropyl methane sulfonate. Sequencing revealed a missense T-to-A transversion in the fourth transmembrane domain, causing a leucine to glutamine substitution. Western blot showed a 167-kDa protein in both mutants and wild-types. (J:92612)
• Inheritance: Dominant

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Casr Mutation: 55 strains or lines available

Notes

Isopropyl methane sulfonate induced

References

• Original: J:92612 Hough TA, et al., Activating calcium-sensing receptor mutation in the mouse is associated with cataracts and ectopic calcification. Proc Natl Acad Sci U S A. 2004 Sep 14;101(37):13566-71
• All: 5 reference(s)