Tg(tetFosb)4468Nes
Transgene Detail

Summary

• Symbol: Tg(tetFosb)4468Nes
• Name: transgene insertion 4468, Eric Nestler
• MGI ID: MGI:3053111
• Synonyms: TetOp-deltaFosB line 11, TetOp-*FosB line 11
• Transgene: Tg(tetFosb)4468Nes Location: unknown
• Alliance: Tg(tetFosb)4468Nes page

Transgene origin

• Strain of Origin: (SJL x C57BL/6)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(tetFosb)4468Nes expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Fosb (MGI:95575)

• Mutation details: The transgene contains a Fosb cDNA under the control of a tetracycline-regulated promoter, an SV40 intron, and a poly A signal sequence. (J:92225)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Homozygous transgenic mice are viable and fertile. These mice express a truncated variant of the Fosb transcription factor. The expressed variant is a highly stable isoform found to be induced in the brain (nucleus accumbens) with repeated exposure to commonly abused drugs, such as amphetamine, morphine, nicotine, and phencyclidine. Transcription is directed by a tetracycline-responsive promoter element (TRE). In bitransgenic mice produced by breeding a mouse carrying this transgene with a transgenic mouse expressing tetracycline-controlled transactivator protein (tTA), Fosb expression can be negatively regulated with the tetracycline analog, doxycycline.

References

• Original: J:92225 Chen J, et al., Transgenic animals with inducible, targeted gene expression in brain. Mol Pharmacol. 1998 Sep;54(3):495-503
• All: 18 reference(s)