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Tg(BCL2)22Wehi
Transgene Detail
Nomenclature
Symbol: Tg(BCL2)22Wehi
Name: transgene insertion 22, Walter and Eliza Hall Institute of Medical Research
MGI ID: MGI:3052827
Synonyms: 22Wehi, C-Emu-bcl-2-22, Emu2-22, Emu-bcl-2, Emu-bcl-2-22, EmuBcl-2.22, SV40-E-hbcl-2-22
Transgene: Tg(BCL2)22Wehi  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6JWehi x SJL/JWehi)F2
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(BCL2)22Wehi expresses 1 gene
 
Mutation detailsThe transgene construct consists of the human BCL2 cDNA in association with the Emu immunoglobulin heavy chain enhancer and SV40 promoter. (J:93111)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Notes
In transgenic mice on a C57BL/6 background, expression of the transgene is restricted to the B cell lineage (no T-cell expression).

References
Original:  J:93111 Strasser A, et al., Abnormalities of the immune system induced by dysregulated bcl-2 expression in transgenic mice. Curr Top Microbiol Immunol. 1990;166:175-81
All:  71 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory