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Targeted Allele Detail
Symbol: Terttm1Yjc
Name: telomerase reverse transcriptase; targeted mutation 1, Y Jeffrey Chiang
MGI ID: MGI:3052737
Synonyms: mTERT-, TERT-
Gene: Tert  Location: Chr13:73626911-73649843 bp, + strand  Genetic Position: Chr13, 40.12 cM
Germline Transmission:  Earliest citation of germline transmission: J:92243
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA GFPneo was inserted into the 5' UTR of exon 1. Southern blot and PCR confirmed recombination in mutant mice. RT-PCR showed a lack of transcript in mutants and a telomerase repeat amplification (TRAP) assay indicated there was no telomerase activity in testis cell extracts from mutants. (J:92243)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tert Mutation:  35 strains or lines available
Original:  J:92243 Chiang YJ, et al., Expression of telomerase RNA template, but not telomerase reverse transcriptase, is limiting for telomere length maintenance in vivo. Mol Cell Biol. 2004 Aug;24(16):7024-31
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
The Jackson Laboratory