About   Help   FAQ
Terttm1Yjc
Targeted Allele Detail
Nomenclature
Symbol: Terttm1Yjc
Name: telomerase reverse transcriptase; targeted mutation 1, Y Jeffrey Chiang
MGI ID: MGI:3052737
Synonyms: mTERT-, TERT-
Gene: Tert  Location: Chr13:73627001-73649041 bp, + strand  Genetic Position: Chr13, 40.12 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:92243
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA GFPneo was inserted into the 5' UTR of exon 1. Southern blot and PCR confirmed recombination in mutant mice. RT-PCR showed a lack of transcript in mutants and a telomerase repeat amplification (TRAP) assay indicated there was no telomerase activity in testis cell extracts from mutants. (J:92243)
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tert Mutation:  4 strains or lines available
References
Original:  J:92243 Chiang YJ, et al., Expression of telomerase RNA template, but not telomerase reverse transcriptase, is limiting for telomere length maintenance in vivo. Mol Cell Biol. 2004 Aug;24(16):7024-31
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/25/2015
MGI 6.0
The Jackson Laboratory