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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Terttm1Yjc
targeted mutation 1, Y Jeffrey Chiang
MGI:3052737
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Terttm1Yjc/Terttm1Yjc involves: 129/Sv * C57BL/6 * SJL * SPRET/Ei MGI:3700912
hm2
 		Terttm1Yjc/Terttm1Yjc involves: C57BL/6 * SPRET/Ei MGI:3053681
hm3
 		Terttm1Yjc/Terttm1Yjc Not Specified MGI:8350133
ht4
 		Terttm1Yjc/Tert+ involves: C57BL/6 * SPRET/Ei MGI:3053682


Genotype
MGI:3700912
hm1
Allelic
Composition		 Terttm1Yjc/Terttm1Yjc
Genetic
Background		 involves: 129/Sv * C57BL/6 * SJL * SPRET/Ei
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Terttm1Yjc mutation (1 available); any Tert mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal telomere length ( J:92243 )
• telomeres are not elongated in Terc-deficient x SPRET/Ei mice as they are in Terc-sufficient x SPRET/Ei mice




Genotype
MGI:3053681
hm2
Allelic
Composition		 Terttm1Yjc/Terttm1Yjc
Genetic
Background		 involves: C57BL/6 * SPRET/Ei
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Terttm1Yjc mutation (1 available); any Tert mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal telomere length ( J:92243 )
• telomeres are not elongated in Tert-deficient x SPRET/Ei mice as they are in Tert-sufficient x SPRET/Ei mice




Genotype
MGI:8350133
hm3
Allelic
Composition		 Terttm1Yjc/Terttm1Yjc
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Terttm1Yjc mutation (1 available); any Tert mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
decreased susceptibility to colitis induced morbidity/mortality ( J:385925 )
• no weight loss after DSS administration
• no or less severe colon shortening after DSS administration
• less perturbed colon morphology, lower disease score and lower CD45+ cell enrichment in colon after DSS administration

immune system
decreased susceptibility to colitis induced morbidity/mortality ( J:385925 )
• no weight loss after DSS administration
• no or less severe colon shortening after DSS administration
• less perturbed colon morphology, lower disease score and lower CD45+ cell enrichment in colon after DSS administration

mortality/aging
decreased susceptibility to colitis induced morbidity/mortality ( J:385925 )
• no weight loss after DSS administration
• no or less severe colon shortening after DSS administration
• less perturbed colon morphology, lower disease score and lower CD45+ cell enrichment in colon after DSS administration




Genotype
MGI:3053682
ht4
Allelic
Composition		 Terttm1Yjc/Tert+
Genetic
Background		 involves: C57BL/6 * SPRET/Ei
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Terttm1Yjc mutation (1 available); any Tert mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
cellular phenotype ( J:92243 )
N
• telomere length is unaffected




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
06/09/2026
MGI 6.24 		The Jackson Laboratory