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Tg(CD3E)26Cpt
Transgene Detail
Nomenclature
Symbol: Tg(CD3E)26Cpt
Name: transgene insertion 26, Cox Terhorst
MGI ID: MGI:3052629
Synonyms: CD3epsilon, CD3epsilontg26, tgE26, Tgepsilon26
Transgene: Tg(CD3E)26Cpt  Location: Chr17:25708849-26016019 bp  Genetic Position: Chr17, Syntenic
Transgene
origin
Strain of Origin:  (C57BL/6J x CBA/J)F2
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(CD3E)26Cpt expresses 1 gene
 
Mutation detailsThe transgene contains a human gene encoding the CD3 antigen, epsilon polypeptide sequences. 30-35 copies of the transgene integrated into the genome between Sstr5 and Metrn on Chromosome 17, accompanied by duplication of the neighboring genomic region spanning 323 kb. Genes surrounding the integrated tg26 transgene are not disrupted. (J:81711, J:168333)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
References
Original:  J:81711 Wang B, et al., A block in both early T lymphocyte and natural killer cell development in transgenic mice with high-copy numbers of the human CD3E gene. Proc Natl Acad Sci U S A. 1994 Sep 27;91(20):9402-6
All:  30 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory