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Tg(APOA1)1Rub
Transgene Detail
Nomenclature
Symbol: Tg(APOA1)1Rub
Name: transgene insertion 1, Edward M Rubin
MGI ID: MGI:3052540
Synonyms: A1Tg, ApoA1Tg, apoA-I/A-IKO, ApoA-Itg, hA-I, hapoA1, hApoA-I/Tg, Hu apo AI
Transgene: Tg(APOA1)1Rub  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(APOA1)1Rub expresses 1 gene
    The transgene contains the human apolipoprotein A-I gene including the promoter. (J:42425)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Notes
Transgenic mice display a two fold increase in total plasma cholesterol levels and greater than a four fold decrease in the levels of mouse APOA1. Two lines were produced, A2 and A16.
References
Original:  J:42425 Rubin EM, et al., Expression of human apolipoprotein A-I in transgenic mice results in reduced plasma levels of murine apolipoprotein A-I and the appearance of two new high density lipoprotein size subclasses. Proc Natl Acad Sci U S A. 1991 Jan 15;88(2):434-8
All:  40 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/18/2019
MGI 6.14
The Jackson Laboratory