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Targeted Allele Detail
Symbol: Ciitatm2Wrth
Name: class II transactivator; targeted mutation 2, Walter Reith
MGI ID: MGI:3052223
Synonyms: C2ta p(III+IV)-, CiitaIII-IV-, CIITA p(III+IV)-, PIII+IV-
Gene: Ciita  Location: Chr16:10297923-10346282 bp, + strand  Genetic Position: Chr16, 5.65 cM, cytoband B1
Germline Transmission:  Earliest citation of germline transmission: J:92170
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsA loxP site was inserted 560 bp upstream of the ATG for the pIII transcript and another loxP site was inserted 90 bp downstream of the first exon encoding the pIV transcript, followed by an FRT-flanked neo. Transient FLP recombinase expression excised the neo and mice generated were crossed with CMV-Cre mice to excise the floxed pIII and pIV sequence. RT-PCR indicated transcripts of both were undetectable in mutant tissues. Gene expression from pI was unaffected. (J:92170)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ciita Mutation:  23 strains or lines available
Original:  J:92170 LeibundGut-Landmann S, et al., MHC class II expression is differentially regulated in plasmacytoid and conventional dendritic cells. Nat Immunol. 2004 Sep;5(9):899-908
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.17
The Jackson Laboratory