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Targeted Allele Detail
Symbol: Hrtm1Cct
Name: lysine demethylase and nuclear receptor corepressor; targeted mutation 1, Catherine C Thompson
MGI ID: MGI:3052135
Synonyms: Hr-
Gene: Hr  Location: Chr14:70554056-70573548 bp, + strand  Genetic Position: Chr14, 36.32 cM
Characterization of the Hrtm1Cct/Hrtm1Cct mouse

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:92053
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 8-10 were replaced with a floxed PGK-neo cassette. Southern blot confirmed recombination in mutant mice. Northern blot of mutant skin indicated lack of full-length mRNA and Western blot showed a lack of full-length protein in the skin of mutants. (J:92053)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hr Mutation:  28 strains or lines available
Original:  J:92053 Zarach JM, et al., The co-repressor hairless has a role in epithelial cell differentiation in the skin. Development. 2004 Sep;131(17):4189-200
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory