Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hrtm1Cct mutation
(1 available);
any
Hr mutation
(84 available)
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integument
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• BY P22, mice exhibit hair loss
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• abnormal epidermal structures (utricles) form by P22; skin is grossly abnormal
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Allelic
Composition |
Hrtm1Cct/Hrtm1Cct
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Genetic
Background |
involves: 129/Sv * C57BL/6 |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hrtm1Cct mutation
(1 available);
any
Hr mutation
(84 available)
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integument
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• first postnatal hair coat grows normally
• hair loss begins around age 18 and starts at the head, proceeding caudally in a scattered pattern
• hair follicles fail to regenerate
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• by day 12, pilary canal widens to form a utricle
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• small dermal cysts appear as hair is lost; these cysts increase in size with age due to cell proliferation and secretion of sebum into sealed compartments while utricle size remains constant
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• skin becomes progressively more wrinkled with age
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• increased cell proliferation in epidermis and utricles
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growth/size/body
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• small dermal cysts appear as hair is lost; these cysts increase in size with age due to cell proliferation and secretion of sebum into sealed compartments while utricle size remains constant
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|
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hrtm1Cct mutation
(1 available);
any
Hr mutation
(84 available)
Tg(KRT14-Hr)551Cct mutation
(1 available)
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integument
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• by P22, mice exhibit hair loss; however mice regenerate hair and display thick fur by P28
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• at P22, follicle morphology is abnormal; by P28, regenerated hair follicles resemble wild-type follicles
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• abnormal epidermal structures (utricles) form by P22
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Analysis Tools
