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Slc29a1tm1Msg
Targeted Allele Detail
Nomenclature
Symbol: Slc29a1tm1Msg
Name: solute carrier family 29 (nucleoside transporters), member 1; targeted mutation 1, Robert O Messing
MGI ID: MGI:3052066
Synonyms: ENT1-
Gene: Slc29a1  Location: Chr17:45585200-45599606 bp, - strand  Genetic Position: Chr17, 22.59 cM, cytoband C
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:92100
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe targeting construct included exons 2-4 of the gene and a neomycin cassette flanked by loxP sequences. Clones were transfected with a Cre plasmid. ES cell lines showing a deletion of exons 2-4 and the neomycin cassette were selected for microinjection. The mutation was confirmed by PCR, Southern blot and in situ hybridization. (J:92100)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Slc29a1 Mutation:  23 strains or lines available
Notes

ES cell line derived from 129X1/SvJ

References
Original:  J:92100 Choi DS, et al., The type 1 equilibrative nucleoside transporter regulates ethanol intoxication and preference. Nat Neurosci. 2004 Aug;7(8):855-61
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory