Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc29a1tm1Msg mutation
(1 available);
any
Slc29a1 mutation
(40 available)
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hematopoietic system
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• adenosine uptake is almost completely abolished
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homeostasis/metabolism
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc29a1tm1Msg mutation
(1 available);
any
Slc29a1 mutation
(40 available)
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homeostasis/metabolism
skeleton
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• sternocostal articulations show calcification at 6 months
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• ectopic calcification of spinal tissues, with calcification in the paraspinal tissues of the cervical spine and in the rib entheses of the upper thoracic spine at 2 months and progressing caudally along the spine at 6 months
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• the intervertebral disc shows ectopic calcification at 6 months of age
• thoracic spine shows hypermineralized material within the lateral aspect of the intervertebral disc at 6 months of age
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• ectopic calcification of spinal tissues, with calcification in the paraspinal tissues of the cervical spine and in the rib entheses of the upper thoracic spine at 2 months and progressing caudally along the spine at 6 months
• sternocostal articulations and interverterbral discs show ectopic calcification at 6 months
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• mice exhibit progressive ectopic mineralization of spinal tissues
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc29a1tm1Msg mutation
(1 available);
any
Slc29a1 mutation
(40 available)
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behavior/neurological
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• voluntarily consume more ethanol compared to wild-type littermates
• increase in consumption is not related to a change in taste preference as no difference in preference for saccharin or quinine is seen
• administration of an A1 receptor agonist reduces alcohol consumption and preference in mutant but not wild-type mice
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• the severity of ethanol-induced motor incoordination and loss of righting reflex is reduced compared to wild-type controls
• however, blood ethanol concentrations do not differ from wild-type
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nervous system
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• incubation of brain slices with an A1 receptor antagonist (1,3-dipropyl-8-cyclopentylxanthine) fails to increase evoked EPSC amplitude unlike in wild-type littermate brain slices
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• the frequency of spontaneous EPSCs in the striatum is increased 2.5-fold compared to wild-type littermates
• the increase in frequncy is associated with a slight but significant increase in amplitude
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growth/size/body