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Dapk1tm1Yuk
Targeted Allele Detail
Nomenclature
Symbol: Dapk1tm1Yuk
Name: death associated protein kinase 1; targeted mutation 1, Kazunori Yukawa
MGI ID: MGI:3052030
Synonyms: DAPK
Gene: Dapk1  Location: Chr13:60601947-60763185 bp, + strand  Genetic Position: Chr13, 32.53 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:92102
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsInsertion of a neomycin resistance gene deleted part of the exon encoding amino acids 22-95 in the catalytic kinase domain. The replaced region encodes a conserved lysine residue that is critical for the kinase activity of the gene. Western blot analysis demonstrated the existence of the mutant protein with a slightly smaller size that wild-type. RT-PCR analysis of kidneys identified the alternative transcript. (J:92102)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dapk1 Mutation:  73 strains or lines available
References
Original:  J:92102 Yukawa K, et al., Deletion of the kinase domain in death-associated protein kinase attenuates renal tubular cell apoptosis in chronic obstructive uropathy. Int J Mol Med. 2004 Apr;13(4):515-20
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory