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St8sia2tm1Jxm
Targeted Allele Detail
Nomenclature
Symbol: St8sia2tm1Jxm
Name: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2; targeted mutation 1, Jamey Marth
MGI ID: MGI:3051219
Synonyms: St8sia-II-
Gene: St8sia2  Location: Chr7:73939119-74013690 bp, - strand  Genetic Position: Chr7, 42.27 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:91777
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 4, encoding a significant portion of the sailyl motif L, was deleted upon Cre mediated deletion of the floxed region including the exon and a tk-neo cassette. Southern blot confirmed recombination and RT-PCR indicated that the truncated form of mRNA was produced in heterozygous and homozygous mutants. The mutant cDNA was found to be inactive. (J:91777)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any St8sia2 Mutation:  1 strain or line available
References
Original:  J:91777 Angata K, et al., Sialyltransferase ST8Sia-II assembles a subset of polysialic acid that directs hippocampal axonal targeting and promotes fear behavior. J Biol Chem. 2004 Jul 30;279(31):32603-13
All:  21 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory